To celebrate the organization's 50-year anniversary in 2015, Americas Society honored Mexican artist Gabriel Orozco with its first Cultural Achievement Award. The occasion featured a conversation between Orozco and Dr. Siddhartha Mukherjee, a Rhodes Scholar and leading cancer physician who won a Pulitzer Prize for his 2010 book The Emperor of All Maladies: A Biography of Cancer. The conversation addressed the artist's ouvre as well as elements in Indian culture such as mandalas that have influenced his work. 

The Americas Society Cultural Achievement Award, which recognizes extraordinary creativity and artistic mastery among Latin American cultural figures, was presented for the first time at a dinner and award ceremony on November 4 at the Society’s landmark building on Park Avenue in New York. The evening was sponsored by the international auction house Phillips.