The Brazil Study Group (BSG), funded by the Tinker Foundation, was charged in 2005 to create informed discussion around Brazilian prospects for reform and economic growth, institutional consolidation, and Brazil's role in the expanding global economy. In a joint program with Columbia University's Center for Brazilian Studies, BSG hosts political and economic analysts, academics, business leaders, and major political figures.

The Council of the Americas launched the Energy Action Group (EAG) in September 2004 to work toward energy cooperation and understanding in the Western Hemisphere. The Group works to identify financial, macroeconomic, industry and business specific issues of concern and solutions.

Funded by the Rockefeller Foundation, the AS/COA Hispanic Integration Initiative works both nationally and in what are referred to as new gateway cities to highlight and build on private-sector efforts to facilitate Hispanic integration while demonstrating how integration programs benefit both business and the community.

The North American Business Committee (NABC) is the oldest private sector business organization with a focus on economic, commercial, and political relations in North America.

The U.S., Canada, and Mexico launched the North American Competitiveness Council (NACC), a partnership between the government and business executives from the three countries with the goal of boosting North American competitiveness. COA and the U.S. Chamber of Commerce jointly serve as the secretariat for the United States.

The Rule of Law Working Group brings together leaders across a variety of sectors to develop an agenda for improving the rule of law in the Americas.

The Council of the Americas launched the Trade Advisory Group (TAG) in 2004, consisting of the leading experts on trade policy. It provides guidance to the Council on trade and investment related issues, and takes part in exclusive dialogues with relevant U.S. Government and Latin American officials.